Discovery of Naphthyl-Fused 5-Membered Lactams as a New Class of M1 Positive Allosteric Modulators-Reference-Cited by-同舟云学术

Discovery of Naphthyl-Fused 5-Membered Lactams as a New Class of M1 Positive Allosteric Modulators

Published:2014-02-26 Issue:5 Volume:5 Page:604-608
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Yang Zhi-Qiang¹,Shu Youheng¹,Ma Lei¹,Wittmann Marion¹,Ray William J.¹,Seager Matthew A.¹,Koeplinger Kenneth A.¹,Thompson Charles D.¹,Hartman George D.¹,Bilodeau Mark T.¹,Kuduk Scott D.¹

Affiliation:

1. Departments of Medicinal Chemistry, ‡Alzheimer’s Research, and §Drug Metabolism, Merck Research Laboratories, Sumneytown Pike, West Point, Pennsylvania 19486, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml500055h

Reference20 articles.

1. Abnormalities of neural circuitry in Alzheimer's disease: Hippocampus and cortical cholinergic innervation

2. The molecular basis of muscarinic receptor diversity

3. Muscarinic acetylcholine receptor expression in memory circuits: Implications for treatment of Alzheimer disease

4. Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

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