3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-Dioxides Structurally Related to Diazoxide and Pinacidil as Potassium Channel Openers Acting on Vascular Smooth Muscle Cells: Design, Synthesis, and Pharmacological Evaluation-Reference-Cited by-同舟云学术

3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-Dioxides Structurally Related to Diazoxide and Pinacidil as Potassium Channel Openers Acting on Vascular Smooth Muscle Cells: Design, Synthesis, and Pharmacological Evaluation

Published:2000-04-01 Issue:8 Volume:43 Page:1456-1466
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pirotte Bernard¹,Ouedraogo Raogo¹,de Tullio Pascal¹,Khelili Smail¹,Somers Fabian¹,Boverie Stéphane¹,Dupont Léon¹,Fontaine Jeanine¹,Damas Jacques¹,Lebrun Philippe¹

Affiliation:

1. Laboratoire de Chimie Pharmaceutique, Université de Liège, 1, Avenue de l'Hôpital, CHU, tour 4, B-4000 Liège, Belgium; Laboratoire de Pharmacodynamie et de Thérapeutique, Université Libre de Bruxelles, 808, Route de Lennik, B-1070 Bruxelles, Belgium; Unité de Cristallographie, Université de Liège, 17, Allée du 6-Août, Sart Tilman, B-4000 Liège, Belgium; Laboratoire de Pharmacologie, Université Libre de Bruxelles, Campus Plaine, CP 205/7, Boulevard du Triomphe, B-1050 Bruxelles, Belgium; and Département...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm991069o

Reference31 articles.

1. The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity

2. Hyperpolarizing Vasodilators Activate ATP-sensitive K + Channels in Arterial Smooth Muscle

3. ATP-sensitive and inwardly rectifying potassium channels in smooth muscle

4. 3-(Alkylamino)-4H-pyrido[4,3-e]1,2,4-thiadiazine 1,1-dioxides as powerful inhibitors of insulin release from rat pancreatic B-cells: a new class of potassium channel openers?

5. 3- and 4-Substituted 4H-Pyrido[4,3-e]-1,2,4-thiadiazine 1,1-Dioxides as Potassium Channel Openers: Synthesis, Pharmacological Evaluation, and Structure−Activity Relationships

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