Identification of 2-(4-Benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an Orally Efficacious Melanin-Concentrating Hormone Receptor 1 Antagonist for the Treatment of Obesity-Reference-Cited by-同舟云学术

Identification of 2-(4-Benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an Orally Efficacious Melanin-Concentrating Hormone Receptor 1 Antagonist for the Treatment of Obesity

Published:2005-02-15 Issue:5 Volume:48 Page:1318-1321
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Souers Andrew J.¹,Gao Ju¹,Brune Michael¹,Bush Eugene¹,Wodka Dariusz¹,Vasudevan Anil¹,Judd Andrew S.¹,Mulhern Mathew¹,Brodjian Sevan¹,Dayton Brian¹,Shapiro Robin¹,Hernandez Lisa E.¹,Marsh Kennan C.¹,Sham Hing L.¹,Collins Christine A.¹,Kym Philip R.¹

Affiliation:

1. Metabolic Disease Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0490890

Reference14 articles.

1. Melanin-concentrating Hormone Receptor: An Orphan Receptor Fits the Key

2. Central nervous system control of food intake

3. Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague–Dawley rats

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