Mechanistic Basis for Suicide Inactivation of Porphobilinogen Synthase by 4,7-Dioxosebacic Acid, an Inhibitor That Shows Dramatic Species Selectivity-Reference-Cited by-同舟云学术

Mechanistic Basis for Suicide Inactivation of Porphobilinogen Synthase by 4,7-Dioxosebacic Acid, an Inhibitor That Shows Dramatic Species Selectivity

Published:2001-06-16 Issue:28 Volume:40 Page:8227-8236
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Kervinen Jukka¹,Jaffe Eileen K.¹,Stauffer Frédéric¹,Neier Reinhard¹,Wlodawer Alexander¹,Zdanov Alexander¹

Affiliation:

1. Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, Department of Chemistry, University of Neuchatel, Neuchatel 2007, Switzerland, and Macromolecular Structure Laboratory, National Cancer Institute, Frederick, Maryland 21702

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi010656k

Reference37 articles.

1. Erskine, P. T., Norton, E., Cooper, J. B., Lambert, R., Coker, A., Lewis, G., Spencer, P., Sarwar, M., Wood, S. P., Warren, M. J., and Shoolingin-Jordan, P. M. (1999)Biochemistry38, 4266−4276.

2. High resolution crystal structure of a Mg2+-dependent porphobilinogen synthase

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