1. Department of Hard Tissue Research, Graduate School of Oral Medicine, Matsumoto Dental University, School of Dentistry, Shiojiri, Nagano 399-0781, Japan, Determent of Applied Biological Science, Faculty of Life Science and Biotechnology, Fukuyama University, Gakuen-cho, Fukuyama 729-0292, Japan, and Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Gakuen-cho, Fukuyama 729-0292, Japan