Potent, Orally Active GPIIb/IIIa Antagonists Containing a Nipecotic Acid Subunit. Structure−Activity Studies Leading to the Discovery of RWJ-53308-Reference-Cited by-同舟云学术

Potent, Orally Active GPIIb/IIIa Antagonists Containing a Nipecotic Acid Subunit. Structure−Activity Studies Leading to the Discovery of RWJ-53308

Published:1999-11-13 Issue:25 Volume:42 Page:5254-5265
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hoekstra William J.¹,Maryanoff Bruce E.¹,Damiano Bruce P.¹,Andrade-Gordon Patricia¹,Cohen Judith H.¹,Costanzo Michael J.¹,Haertlein Barbara J.¹,Hecker Leonard R.¹,Hulshizer Becky L.¹,Kauffman Jack A.¹,Keane Patricia¹,McComsey David F.¹,Mitchell John A.¹,Scott Lorraine¹,Shah Rekha D.¹,Yabut Stephen C.¹

Affiliation:

1. Drug Discovery and New Product Research, The R. W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm990418b

Reference35 articles.

1. The platelet membrane glycoprotein IIb-IIIa complex

2. Cardiogenic Shock

3. Eptifibatide

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