Enantiospecific Formal Total Synthesis of the Tumor and GSK-3β Inhibiting Alkaloid, (−)-Agelastatin A-Reference-Cited by-同舟云学术

Enantiospecific Formal Total Synthesis of the Tumor and GSK-3β Inhibiting Alkaloid, (−)-Agelastatin A

Published:2003-07-12 Issue:16 Volume:5 Page:2927-2930
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Hale Karl J.¹,Domostoj Mathias M.¹,Tocher Derek A.¹,Irving Ed¹,Scheinmann Feodor¹

Affiliation:

1. The Christopher Ingold Laboratories, University College London, 20 Gordon Street, London WC1H 0AJ, England, and The Medicinal Chemistry Department, Ultrafine, Synergy House, Guildhall Close, Manchester Science Park, Manchester M15 6SY, England

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ol035036l

Reference38 articles.

1. Agelastatin a, a new skeleton cytotoxic alkaloid of the oroidin family. Isolation from the axinellid sponge Agelas dendromorpha of the coral sea

2. Conformational Preferences and Absolute Configuration of Agelastatin A, a Cytotoxic Alkaloid of the Axinellid SpongeAgelas dendromorpha from the Coral Sea,via combined molecular modelling, NMR, and exciton splitting for diamide and hydroxyamide derivatives

3. The Active Centres of Agelastatin A, a Strongly Cytotoxic Alkaloid of the Coral Sea Axinellid SpongeAgelas dendromorpha, as Determined by Comparative Bioassays with Semisynthetic Derivatives

4. Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent

5. Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells

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