Chloro-Substituted 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-Dioxides as ATP-Sensitive Potassium Channel Activators: Impact of the Position of the Chlorine Atom on the Aromatic Ring on Activity and Tissue Selectivity-Reference-Cited by-同舟云学术

Chloro-Substituted 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-Dioxides as ATP-Sensitive Potassium Channel Activators: Impact of the Position of the Chlorine Atom on the Aromatic Ring on Activity and Tissue Selectivity

Published:2009-11-18 Issue:1 Volume:53 Page:147-154
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pirotte Bernard¹,de Tullio Pascal¹,Nguyen Quynh-Anh²,Somers Fabian¹,Fraikin Pierre¹,Florence Xavier¹,Wahl Philip³,Hansen John Bondo³,Lebrun Philippe²

Affiliation:

1. Laboratoire de Chimie Pharmaceutique, Centre Interfacultaire de Recherche du Médicament (Drug Research Center), Université de Liège, 1 Avenue de l’Hôpital, B-4000 Liège, Belgium

2. Laboratoire de Pharmacodynamie et de Thérapeutique, Université Libre de Bruxelles, Faculté de Médecine, 808 Route de Lennik, B-1070 Bruxelles, Belgium

3. Research and Development, Novo Nordisk, Målo̷v, Denmark

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9010093

Reference26 articles.

1. The Sulfonylurea Receptor, an Atypical ATP-Binding Cassette Protein, and Its Regulation of the KATPChannel

2. ATP-SENSITIVE POTASSIUM CHANNELS: A Model of Heteromultimeric Potassium Channel/Receptor Assemblies

3. Function and distribution of the SUR isoforms and splice variants

4. Mitochondrial K channels in cell survival and death

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