1. Department of Biochemistry and Molecular Biology, Nippon Medical School, 1-1-5 Sendagi, Bunkyou-ku, Tokyo 113-8602, Japan, Departments of Biochemistry, Medical Biophysics, and Molecular Genetics, University of Toronto and The Campbell Family Cancer Research Institute, University Health Network, Toronto, Ontario M5S1A8, Canada, and Department of Biochemistry, 1463 Boyce Hall, University of California, Riverside, 92521-0122, United States