Active Site Gating and Substrate Specificity of Butyrylcholinesterase and Acetylcholinesterase: Insights from Molecular Dynamics Simulations-Reference-Cited by-同舟云学术

Active Site Gating and Substrate Specificity of Butyrylcholinesterase and Acetylcholinesterase: Insights from Molecular Dynamics Simulations

Published:2011-06-17 Issue:27 Volume:115 Page:8797-8805
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Fang Lei¹,Pan Yongmei¹,Muzyka Jennifer L.¹,Zhan Chang-Guo¹

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, Kentucky 40536, United States

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jp112030p

Reference43 articles.

1. Crystal Structure of Human Butyrylcholinesterase and of Its Complexes with Substrate and Products

2. The Molecular Forms of Cholinesterase and Acetylcholinesterase in Vertebrates

3. Dynamics of the Acetylcholinesterase Tetramer

4. Molecular Dynamics of Acetylcholinesterase Dimer Complexed with Tacrine

5. Conformation gating as a mechanism for enzyme specificity

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