Overcoming Drug Resistance to Heme-Targeted Antimalarials by Systematic Side Chain Variation of 7-Chloro-4-aminoquinolines-Reference-Cited by-同舟云学术

Overcoming Drug Resistance to Heme-Targeted Antimalarials by Systematic Side Chain Variation of 7-Chloro-4-aminoquinolines

Published:2008-03-18 Issue:7 Volume:51 Page:1995-1998
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yearick Kimberly¹,Ekoue-Kovi Kekeli¹,Iwaniuk Daniel P.¹,Natarajan Jayakumar K.¹,Alumasa John¹,de Dios Angel C.¹,Roepe Paul D.¹,Wolf Christian¹

Affiliation:

1. Department of Chemistry, Department of Biochemistry and Cellular and Molecular Biology, and Center for Infectious Diseases, Georgetown University, 37th and O Streets, Washington, D.C.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800106u

Reference39 articles.

1. Antimalarials: Synthesis of 4-aminoquinolines that circumvent drug resistance in malaria parasites

2. 4-Aminoquinolines—Past, present, and future; A chemical perspective

3. Chemotherapeutic Agents Against Malaria: What Next After Chloroquine?

4. The structure of malaria pigment β-haematin

5. Medical need, scientific opportunity and the drive for antimalarial drugs

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