Hybrid Molecules from Xanomeline and Tacrine: Enhanced Tacrine Actions on Cholinesterases and Muscarinic M1 Receptors-Reference-Cited by-同舟云学术

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Hybrid Molecules from Xanomeline and Tacrine: Enhanced Tacrine Actions on Cholinesterases and Muscarinic M1 Receptors

Published:2010-02-16 Issue:5 Volume:53 Page:2094-2103
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Fang Lei¹²,Jumpertz Sabine³,Zhang Yihua¹,Appenroth Dorothea⁴,Fleck Christian⁴,Mohr Klaus³,Tränkle Christian³,Decker Michael²

Affiliation:

1. Center of Drug Discovery, China Pharmaceutical University, 210009 Nanjing, P. R. China

2. Lehrstuhl für Pharmazeutische/Medizinische Chemie, Institut für Pharmazie, Friedrich-Schiller-Universität Jena, D-07743 Jena, Germany

3. Pharmazeutisches Institut, Rheinische Friedrich-Wilhelms-Universität Bonn, D-53121, Germany

4. Institut für Pharmakologie und Toxikologie, Friedrich-Schiller-Universität Jena, D-07740 Jena, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901616h

Reference44 articles.

1. Treatment of Alzheimer's disease; current status and new perspectives

2. M1 Muscarinic Agonists Target Major Hallmarks of Alzheimer’s Disease – The Pivotal Role of Brain M1 Receptors

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1. DNA-modularized construction of bivalent ligands precisely regulates receptor binding and activation;Chem;2023-04

2. Current Status of Oligonucleotide-Based Protein Degraders;Pharmaceutics;2023-02-24

3. Tacrine-Based Hybrids: Past, Present, and Future;International Journal of Molecular Sciences;2023-01-15

4. Anticancer Effects with Molecular Docking Confirmation of Newly Synthesized Isatin Sulfonamide Molecular Hybrid Derivatives against Hepatic Cancer Cell Lines;Biomedicines;2022-03-20

5. Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors;Bioorganic Chemistry;2020-03

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