Supercoiled DNA Promotes Formation of Intercalated cis-N2-Deoxyguanine Adducts and Base-Stacked trans-N2-Deoxyguanine Adducts by (+)-7R,8S-Dihydrodiol-9S,10R-epoxy-7,8,9,10-tetra- hydrobenzo[a]pyrene
Author:
Affiliation:
1. Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky 40292, Ames Laboratory, USDOE and Department of Chemistry, Iowa State University, Ames, Iowa 50011, and NIEHS, Research Triangle Park, North Carolina
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/tx034184h
Reference40 articles.
1. Kozack, R. E., Shukla, R., and Loechler, E. L. (1999) A hypothesis for what conformation of the major adduct of (+)-anti-B[a]PDE (N2-dG) causes G → T versus G → A mutations based upon a correlation between mutagenesis and molecular modeling results.Carcinogenesis20(1), 95−102.
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