1. Research Institute of Toxicology (RITOX), University Utrecht, P.O. Box 80.176, 3508 TD Utrecht, The Netherlands, OpdenKamp Adviesgroep BV, Koninginnegracht 23, ‘s-Gravenhage, The Netherlands, Research Institute of Toxicology (RITOX), Utrecht University, Utrecht, The Netherlands, and National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands