β-d-2′-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5′-Triphosphate Forms-Reference-Cited by-同舟云学术

β-d-2′-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5′-Triphosphate Forms

Published:2015-04-07 Issue:8 Volume:58 Page:3445-3458
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhou Longhu¹,Zhang Hong-wang¹,Tao Sijia¹,Bassit Leda¹²,Whitaker Tony³,McBrayer Tamara R.²³,Ehteshami Maryam¹,Amiralaei Sheida¹,Pradere Ugo¹,Cho Jong Hyun¹,Amblard Franck¹²,Bobeck Drew³,Detorio Mervi¹²,Coats Steven J.³,Schinazi Raymond F.¹²

Affiliation:

1. Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, United States

2. Veterans Affairs Medical Center, Decatur, Georgia 30033, United States

3. CoCrystal Pharma, Inc., Tucker, Georgia 30084, United States

Funder

National Institute of Allergy and Infectious Diseases

U.S. Department of Veterans Affairs

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501874e

Reference61 articles.