Reactive Intermediate Formation from the 2-(Fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (Compound A)-Derived Cysteine S-Conjugate S-[2-(Fluoromethoxy)-1,1,3,3,3-pentafluoropropyl]-l-cysteine in Pyridoxal Model Systems-Reference-Cited by-同舟云学术

Reactive Intermediate Formation from the 2-(Fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (Compound A)-Derived Cysteine S-Conjugate S-[2-(Fluoromethoxy)-1,1,3,3,3-pentafluoropropyl]-l-cysteine in Pyridoxal Model Systems

Published:2002-04-05 Issue:5 Volume:15 Page:623-628
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Tong Zeen¹,Anders M. W.¹

Affiliation:

1. Department of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Box 711, Rochester, New York 14620

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx010148b

Reference26 articles.

1. Iyer, R. A., and Anders, M. W. (1997) Cysteine conjugate β-lyase-dependent biotransformation of the cysteineS-conjugates of the sevoflurane degradation product 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (Compound A).Chem. Res. Toxicol.10, 811−819.

2. GLUTATHIONE-DEPENDENT BIOACTIVATION OF HALOALKENES

3. Hayden, P. J., Yang, Y., Ward, A. J. I., Dulik, D. M., McCann, D. J., and Stevens, J. L. (1991) Formation of difluorothionoacetyl-protein adducts byS-(1,1,2,2-tetrafluoroethyl)-l-cysteine metabolites: Nucleophilic catalysis of stable lysyl adduct formation by histidine and tyrosine.Biochemistry30, 5935−5943.

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