Discovery of 5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a Novel Inhibitor of the Jak/Stat Pathway-Reference-Cited by-同舟云学术

Discovery of 5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a Novel Inhibitor of the Jak/Stat Pathway

Published:2010-12-07 Issue:1 Volume:54 Page:262-276
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ioannidis Stephanos¹,Lamb Michelle L.¹,Wang Tao¹,Almeida Lynsie¹,Block Michael H.¹,Davies Audrey M.¹,Peng Bo¹,Su Mei¹,Zhang Hai-Jun¹,Hoffmann Ethan²,Rivard Caroline²,Green Isabelle³,Howard Tina³,Pollard Hannah³,Read Jon³,Alimzhanov Marat⁴,Bebernitz Geraldine⁴,Bell Kirsten⁴,Ye Minwei⁴,Huszar Dennis⁴,Zinda Michael⁴

Affiliation:

1. Department of Cancer Chemistry

2. Department of Drug Metabolism and Pharmacokinetics

3. Discovery Enabling Capabilities and Sciences—Cells, Protein & Structural Sciences, AstraZeneca, Alderley Park, Cheshire, SK10 4TG, United Kingdom

4. Department of Cancer Bioscience

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm1011319

Reference30 articles.