Practical and Economical Implementation of Online H/D Exchange in LC-MS-Reference-Cited by-同舟云学术

Practical and Economical Implementation of Online H/D Exchange in LC-MS

Published:2013-11-08 Issue:22 Volume:85 Page:10904-10912
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Shah Ravi P.¹,Garg Amit²,Putlur Siva Prasad²,Wagh Santosh²,Kumar Vineet²,Rao Venugopala¹,Singh Saranjit³,Mandlekar Sandhya⁴,Desikan Sridhar⁵

Affiliation:

1. Analytical Research and Development, Pharmaceutical Development, Biocon Bristol-Myers Squibb R&D Center, Syngene International Ltd., Bangalore, India

2. Pharmaceutical Candidate Optimization, Biocon Bristol-Myers Squibb R&D Center, Syngene International Ltd., Bangalore, India

3. Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, India

4. Pharmaceutical Candidate Optimization, Biocon Bristol-Myers Squibb R&D Center, Bristol-Myers Squibb India Pvt. Ltd., Bangalore, India

5. Analytical Research and Development, Pharmaceutical Development, Biocon Bristol-Myers Squibb R&D Center, Bristol-Myers Squibb India Pvt. Ltd., Bangalore, India

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ac402339s

Reference21 articles.

1. A critical review on the use of modern sophisticated hyphenated tools in the characterization of impurities and degradation products

2. The use of LC/MS, GC/MS, and LC/NMR hyphenated techniques to identify a drug degradation product in pharmaceutical development

3. Metabolite identification by liquid chromatography-mass spectrometry

4. LC-MS/TOF, LC-MSn, on-line H/D exchange and LC-NMR studies on rosuvastatin degradation and in silico determination of toxicity of its degradation products: a comprehensive approach during drug development

5. Liquid chromatography–mass spectrometry using the hydrogen/deuterium exchange reaction as a tool for impurity identification in pharmaceutical process development

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