Synthesis, Biological Activity, and Crystal Structure of Potent Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase That Retain Activity against Mutant Forms of the Enzyme-Reference-Cited by-同舟云学术

Synthesis, Biological Activity, and Crystal Structure of Potent Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase That Retain Activity against Mutant Forms of the Enzyme

Published:2007-07-31 Issue:17 Volume:50 Page:4003-4015
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Morningstar Marshall L.¹,Roth Thomas¹,Farnsworth David W.¹,Kroeger Smith Marilyn¹,Watson Karen¹,Buckheit, Robert W.¹,Das Kalyan¹,Zhang Wanyi¹,Arnold Eddy¹,Julias John G.¹,Hughes Stephen H.¹,Michejda Christopher J.¹

Affiliation:

1. Molecular Aspects of Drug Design Section and Retroviral Replication Laboratory, National Cancer InstituteFrederick, P.O. Box B, Frederick, Maryland 21702, McDaniel College, Westminster, Maryland 21157, Southern Research InstituteFrederick Research Center, 431 Aviation Way, Frederick, Maryland 21701, and Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060103d

Reference24 articles.

1. Highlights in the Development of New Antiviral Agents

2. Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor

3. Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase.

4. Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

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