Silencing of Pyruvate Kinase M2 via a Metal–Organic Framework Based Theranostic Gene Nanomedicine for Triple-Negative Breast Cancer Therapy

Author:

Huang Siming12,Zhu Wangshu13,Zhang Fang1,Chen Guosheng4ORCID,Kou Xiaoxue4,Yang Xieqing1,Ouyang Gangfeng45ORCID,Shen Jun1ORCID

Affiliation:

1. Department of Radiology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

2. School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China

3. Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China

4. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry/KLGHEI of Environment and Energy Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China

5. Chemistry College, Center of Advanced Analysis and Gene Sequencing, Zhengzhou University, Kexue Avenue 100, Zhengzhou 450001, China

Funder

National Natural Science Foundation of China

Guangdong Province

Publisher

American Chemical Society (ACS)

Subject

General Materials Science

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