3D-Bioprinted Difunctional Scaffold for In Situ Cartilage Regeneration Based on Aptamer-Directed Cell Recruitment and Growth Factor-Enhanced Cell Chondrogenesis

Author:

Yang Zhen12,Zhao Tianyuan12,Gao Cangjian12,Cao Fuyang13,Li Hao12,Liao Zhiyao12,Fu Liwei12,Li Pinxue12,Chen Wei12,Sun Zhiqiang12,Jiang Shuangpeng4,Tian Zhuang1,Tian Guangzhao12,Zha Kangkang12,Pan Tingting5,Li Xu6,Sui Xiang1,Yuan Zhiguo7,Liu Shuyun1,Guo Quanyi12ORCID

Affiliation:

1. Beijing Key Lab of Regenerative Medicine in Orthopedics; Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Institute of Orthopedics, the First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China

2. School of Medicine, Nankai University, Tianjin 300071, China

3. Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, 1 Jian East Road, Eqi District, Zhengzhou 450052, China

4. The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001 Liaoning Province, China

5. Birth Defects Prevention and Control Technology Research Center, Center for Health Research and Innovation, Chinese PLA General Hospital, Beijing 100853, China

6. Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China; Li Ka Shing Health and Science Institute, The Chinese University of Hong Kong, Hong Kong, China; Joint Laboratory of Chinese Academic of Science and Hong Kong for Biomaterials, The Chinese University of Hong Kong, Hong Kong 999077, China

7. Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Chinese PLA General Hospital Medical Youth Program

Publisher

American Chemical Society (ACS)

Subject

General Materials Science

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