1. AstraZeneca, Dept of Drug Metabolism and Pharmacokinetics, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom, Biological Chemistry, Sir Alexander Fleming Building, Imperial College, London, SW7 2AZ, United Kingdom, Waters Corporation, MS Technologies Center, Floats Road, Wythenshawe, Manchester, M23 9LZ, United Kingdom, and Waters Corporation, Milford, Massachusetts