Design and Synthesis of a Novel and Potent Series of Inhibitors of Cytosolic Phospholipase A2 Based on a 1,3-Disubstituted Propan-2-one Skeleton-Reference-Cited by-同舟云学术

Design and Synthesis of a Novel and Potent Series of Inhibitors of Cytosolic Phospholipase A2 Based on a 1,3-Disubstituted Propan-2-one Skeleton

Published:2002-02-08 Issue:6 Volume:45 Page:1348-1362
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Connolly Stephen¹,Bennion Colin¹,Botterell Sarah¹,Croshaw Pamela J.¹,Hallam Catherine¹,Hardy Kim¹,Hartopp Paul¹,Jackson Clive G.¹,King Sarah J.¹,Lawrence Louise¹,Mete Antonio¹,Murray David¹,Robinson David H.¹,Smith Gillian M.¹,Stein Linda¹,Walters Iain¹,Wells Edward¹,Withnall W. John¹

Affiliation:

1. Departments of Medicinal Chemistry, Molecular Biology, and Discovery BioScience, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire LE11 5RH, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm011050x

Reference35 articles.

1. Phospholipase A2 mechanism: Inhibition and role in arachidonic acid release

2. Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): Rationale for selective inhibition and progress to date

3. Patent Update: Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Platelet-activating factor receptor antagonists

4. Patent Update: Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: The search for inhibitors of the phospholipases A2

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