Design, Synthesis, and Activity of 2,6-Diphenoxypyridine-Derived Factor Xa Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Activity of 2,6-Diphenoxypyridine-Derived Factor Xa Inhibitors

Published:1999-04-24 Issue:10 Volume:42 Page:1749-1756
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Phillips Gary¹,Davey David D.¹,Eagen Keith A.¹,Koovakkat Sunil K.¹,Liang Amy¹,Ng Howard P.¹,Pinkerton Michael¹,Trinh Lan¹,Whitlow Marc¹,Beatty Alicia M.¹,Morrissey Michael M.¹

Affiliation:

1. Discovery Research, Berlex Biosciences, 15049 San Pablo Avenue, P.O. Box 4099, Richmond, California 94804-0099

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980667k

Reference17 articles.

1. A communication introducing this material has been published: Phillips, G. B.; Buckman, B. O.; Davey, D. D.; Eagen, K. A.; Guilford, W. J.; Hinchman, J.; Ho, E.; Koovakkat, S.; Liang, A.; Light, D. R.; Mohan, R.; Ng, H. P.; Post, J.; Show, K.; Smith, D.; Subramanyam, B.; Sullivan, M. E.; Trinh, L.; Vergona, R.; Walters, J.; White, K.; Whitlow, M.; Wu, S.; Xu, W.; Morrissey, M. M. Discovery ofN-[2-[5-[amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl-N-methylglycine (ZK-807834): A potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.J. Med. Chem.1998,41, 3557−3562.

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