Design and Biological Activity of (S)-4-(5-{[1-(3-Chlorobenzyl)-2- oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-Aminopyrrolidinone Farnesyltransferase Inhibitor with Excellent Cell Potency-Reference-Cited by-同舟云学术

Design and Biological Activity of (S)-4-(5-{[1-(3-Chlorobenzyl)-2- oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-Aminopyrrolidinone Farnesyltransferase Inhibitor with Excellent Cell Potency

Published:2001-07-31 Issue:18 Volume:44 Page:2933-2949
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bell Ian M.¹,Gallicchio Steven N.¹,Abrams Marc¹,Beshore Douglas C.¹,Buser Carolyn A.¹,Culberson J. Christopher¹,Davide Joseph¹,Ellis-Hutchings Michelle¹,Fernandes Christine¹,Gibbs Jackson B.¹,Graham Samuel L.¹,Hartman George D.¹,Heimbrook David C.¹,Homnick Carl F.¹,Huff Joel R.¹,Kassahun Kelem¹,Koblan Kenneth S.¹,Kohl Nancy E.¹,Lobell Robert B.¹,Lynch Joseph J.¹,Miller Patricia A.¹,Omer Charles A.¹,Rodrigues A. David¹,Walsh Eileen S.¹,Williams Theresa M.¹

Affiliation:

1. Departments of Medicinal Chemistry, Cancer Research, Molecular Systems, Drug Metabolism, and Pharmacology, Merck Research Laboratories, West Point, Pennsylvania 19486

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm010156p

Reference44 articles.

1. Ras C-terminal processing enzymes—New drug targets?

2. Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.

3. p21ras is modified by a farnesyl isoprenoid.

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