1. School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff, CF10 3AT, United Kingdom, CEM Microwave Technology Ltd, 2 Middle Slade, Buckingham, MK18 1WA, United Kingdom, and AstraZeneca R&D, Alderley Park, Macclesfield, Cheshire, SK10 4TF, United Kingdom bagleymc@cf.ac.uk; robinwood@astrazeneca.com