Characterization of the Stereoselective P450 Enzyme BotCYP Enables the In Vitro Biosynthesis of the Bottromycin Core Scaffold-Reference-Cited by-同舟云学术

Characterization of the Stereoselective P450 Enzyme BotCYP Enables the In Vitro Biosynthesis of the Bottromycin Core Scaffold

Published:2020-11-28 Issue:49 Volume:142 Page:20560-20565
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Adam Sebastian¹^ORCID,Franz Laura¹^ORCID,Milhim Mohammed²,Bernhardt Rita²^ORCID,Kalinina Olga V.³⁴,Koehnke Jesko¹⁵^ORCID

Affiliation:

1. Workgroup Structural Biology of Biosynthetic Enzymes, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University, Campus Geb. E8.1, 66123 Saarbrücken, Germany

2. Department of Biochemistry, Saarland University, Campus Geb. B2.2, 66123 Saarbrücken, Germany

3. Research Group Drug Bioinformatics, HIPS, HZI, 66123 Saarbrücken, Germany

4. Faculty of Medicine, Saarland University, 66424 Homburg, Germany

5. School of Chemistry, University of Glasgow, Glasgow G12 8QQ, U.K.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.0c10361

Reference29 articles.

1. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

2. New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products

3. New developments in RiPP discovery, enzymology and engineering

4. Structure and Biosynthesis of the Antibiotic Bottromycin D

5. Structure Determination and Total Synthesis of Bottromycin A2: A Potent Antibiotic against MRSA and VRE

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