Biosynthesis of the Immunosuppressant (−)-FR901483
Author:
Affiliation:
1. Department of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan
2. Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki 300-2611, Japan
Funder
National Institute of General Medical Sciences
Publisher
American Chemical Society (ACS)
Subject
Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis
Link
https://pubs.acs.org/doi/pdf/10.1021/jacs.0c12352
Reference35 articles.
1. FR901483, a Novel Immunosuppressant Isolated from Cladobotryum sp. No. 11231. Taxonomy of the Producing Organism, Fermentation, Isolation,Physico-chemical Properties and Biological Activities.
2. FR901483: Synthetic Efficiency Remains a Challenge
3. Total Synthesis of (−)-FR901483
4. An Enantiospecific Synthesis of the Potent Immunosuppressant FR901483
5. Synthesis of the azatricyclic core of FR901483 by bridgehead vinylation via an anti-Bredt iminium ion
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