Simple Setup for Gas-Phase H/D Exchange Mass Spectrometry Coupled to Electron Transfer Dissociation and Ion Mobility for Analysis of Polypeptide Structure on a Liquid Chromatographic Time Scale-Reference-Cited by-同舟云学术

Simple Setup for Gas-Phase H/D Exchange Mass Spectrometry Coupled to Electron Transfer Dissociation and Ion Mobility for Analysis of Polypeptide Structure on a Liquid Chromatographic Time Scale

Published:2014-11-20 Issue:23 Volume:86 Page:11868-11876
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Mistarz Ulrik H.¹,Brown Jeffery M.²,Haselmann Kim F.³,Rand Kasper D.¹

Affiliation:

1. Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark

2. Waters MS Technologies Centre, Stamford Avenue, Wilmslow SK94AX, U.K.

3. Diabetes Protein Engineering, Novo Nordisk A/S, Novo Nordisk Park 1, 2760 Måløv, Denmark

Funder

European Commission Directorate-General for Research and Innovation

Det Frie Forskningsråd | Natur og Univers

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ac5035456

Reference49 articles.

1. Electrospray Ionization for Mass Spectrometry of Large Biomolecules

2. Structural Stability from Solution to the Gas Phase: Native Solution Structure of Ubiquitin Survives Analysis in a Solvent-Free Ion Mobility–Mass Spectrometry Environment

3. Monitoring Structural Changes of Proteins in an Ion Trap over ∼10−200 ms: Unfolding Transitions in Cytochrome c Ions

4. Stepwise evolution of protein native structure with electrospray into the gas phase, 10-12 to 102 s

5. Biomolecule Analysis by Ion Mobility Spectrometry

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