Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program

Author:

Martin Matthew T.1,Dix David J.1,Judson Richard S.1,Kavlock Robert J.1,Reif David M.1,Richard Ann M.1,Rotroff Daniel M.1,Romanov Sergei1,Medvedev Alexander1,Poltoratskaya Natalia1,Gambarian Maria1,Moeser Matt1,Makarov Sergei S.1,Houck Keith A.1

Affiliation:

1. National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, and Attagene Inc., P.O. Box 12054, Research Triangle Park, North Carolina

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Reference54 articles.

1. Development and Characterization of a Cell Line That Stably Expresses an Estrogen-Responsive Luciferase Reporter for the Detection of Estrogen Receptor Agonist and Antagonists

2. Understanding mechanisms of toxicity: Insights from drug discovery research

3. NRC. ( (2007) National Research Council, Toxicity Testing in the 21st Century: A Vision and a Strategy,National Academy Press,Washington DC.

4. U.S. EPA. ( (2009) EPA ToxCast.http://www.epa.gov/ncct/toxcast/(accessed Aug 8, 2009).

5. Transforming Environmental Health Protection

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