Synthesis and Structure−Activity Relationships of a Novel Series of 2,3,5,6,7,9-Hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide KATP Channel Openers: Discovery of (−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637), a Potent KATP Opener That Selectively Inhibits Spontaneous Bladder Contractions-Reference-Cited by-同舟云学术

Synthesis and Structure−Activity Relationships of a Novel Series of 2,3,5,6,7,9-Hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide KATP Channel Openers: Discovery of (−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637), a Potent KATP Opener That Selectively Inhibits Spontaneous Bladder Contractions

Published:2004-05-04 Issue:12 Volume:47 Page:3163-3179
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Carroll William A.¹,Altenbach Robert J.¹,Bai Hao¹,Brioni Jorge D.¹,Brune Michael E.¹,Buckner Steven A.¹,Cassidy Christopher¹,Chen Yiyuan¹,Coghlan Michael J.¹,Daza Anthony V.¹,Drizin Irene¹,Fey Thomas A.¹,Fitzgerald Michael¹,Gopalakrishnan Murali¹,Gregg Robert J.¹,Henry Rodger F.¹,Holladay Mark W.¹,King Linda L.¹,Kort Michael E.¹,Kym Philip R.¹,Milicic Ivan¹,Tang Rui¹,Turner Sean C.¹,Whiteaker Kristi L.¹,Yi Lin¹,Zhang Henry¹,Sullivan James P.¹

Affiliation:

1. Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, Illinois 60064-6101

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030356w

Reference35 articles.

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2. Smooth muscle of the bladder in the normal and the diseased state: Pathophysiology, diagnosis and treatment

3. Discussion: The neostructural myogenic mechanism of detrusor overactivity

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