Discovery of Geranylgeranyltransferase-I Inhibitors with Novel Scaffolds by the Means of Quantitative Structure−Activity Relationship Modeling, Virtual Screening, and Experimental Validation-Reference-Cited by-同舟云学术

Discovery of Geranylgeranyltransferase-I Inhibitors with Novel Scaffolds by the Means of Quantitative Structure−Activity Relationship Modeling, Virtual Screening, and Experimental Validation

Published:2009-06-18 Issue:14 Volume:52 Page:4210-4220
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Peterson Yuri K.¹,Wang Xiang S.²,Casey Patrick J.¹,Tropsha Alexander²

Affiliation:

1. Department of Pharmacology, Duke University Medical Center, Durham, North Carolina, 27710

2. Laboratory for Molecular Modeling, Division of Medicinal Chemistry and Natural Products and Carolina Exploratory Center for Cheminformatics Research, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8013772

Reference60 articles.

1. PROTEIN PRENYLATION: Molecular Mechanisms and Functional Consequences

2. Farnesyltransferase inhibitors: promises and realities

3. Post-prenylation-processing enzymes as new targets in oncogenesis

4. Protein Prenyltransferases

5. Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues

Cited by 38 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. FNTA facilitates NLRP3 inflammasome activation by enhancing NLRP3 stability;SCIENTIA SINICA Vitae;2024-08-01

2. Inferring molecular inhibition potency with AlphaFold predicted structures;Scientific Reports;2024-04-08

3. Virtual Screening Algorithms in Drug Discovery: A Review Focused on Machine and Deep Learning Methods;Drugs and Drug Candidates;2023-05-05

4. Computational Approach to Drug Penetration across the Blood-Brain and Blood-Milk Barrier Using Chromatographic Descriptors;Cells;2023-01-27

5. Past and Future Strategies to Inhibit Membrane Localization of the KRAS Oncogene;International Journal of Molecular Sciences;2021-12-07