Scaffold Hopping with Molecular Field Points: Identification of a Cholecystokinin-2 (CCK2) Receptor Pharmacophore and Its Use in the Design of a Prototypical Series of Pyrrole- and Imidazole-Based CCK2 Antagonists-Reference-Cited by-同舟云学术

Scaffold Hopping with Molecular Field Points: Identification of a Cholecystokinin-2 (CCK2) Receptor Pharmacophore and Its Use in the Design of a Prototypical Series of Pyrrole- and Imidazole-Based CCK2 Antagonists

Published:2005-10-11 Issue:22 Volume:48 Page:6790-6802
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Low Caroline M. R.¹,Buck Ildiko M.¹,Cooke Tracey¹,Cushnir Julia R.¹,Kalindjian S. Barret¹,Kotecha Atul¹,Pether Michael J.¹,Shankley Nigel P.¹,Vinter J. G.¹,Wright Laurence¹

Affiliation:

1. James Black Foundation, 68 Half Moon Lane, London, SE24 9JE, U.K., and Cresset BioMolecular Discovery Ltd., Spirella Building, Bridge Road, Letchworth, Herts, SG6 4ET, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm049069y

Reference49 articles.

1. Gastrin Agonists and Antagonists

2. A New Class of Non-peptidic Cholecystokinin-B/Gastrin Receptor Antagonists Based on Dibenzobicyclo[2.2.2]octane

3. Improving the Affinity and Selectivity of a Nonpeptide Series of Cholecystokinin-B/Gastrin Receptor Antagonists Based on the Dibenzobicyclo[2.2.2]octane Skeleton

4. Non-Peptide Cholecystokinin-B/Gastrin Receptor Antagonists Based on Bicyclic, Heteroaromatic Skeletons

5. 2,7-Dioxo-2,3,4,5,6,7-hexahydro-1H-benzo[h][1,4]diazonine as a New Template for the Design of CCK2 Receptor Antagonists

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