Crystallographic Study of a Novel Subnanomolar Inhibitor Provides Insight on the Binding Interactions of Alkenyldiarylmethanes with Human Immunodeficiency Virus-1 Reverse Transcriptase-Reference-Cited by-同舟云学术

Crystallographic Study of a Novel Subnanomolar Inhibitor Provides Insight on the Binding Interactions of Alkenyldiarylmethanes with Human Immunodeficiency Virus-1 Reverse Transcriptase

Published:2009-09-23 Issue:20 Volume:52 Page:6467-6473
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cullen Matthew D.¹,Ho William C.²,Bauman Joseph D.²,Das Kalyan²,Arnold Eddy²,Hartman Tracy L.³,Watson Karen M.³,Buckheit Robert W.³,Pannecouque Christophe⁴,De Clercq Erik⁴,Cushman Mark¹

Affiliation:

1. Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, and Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907

2. Department of Chemistry and Chemical Biology, Center for Advanced Biotechnology and Medicine, Rutgers University, 679 Hoes Lane West, Piscataway, New Jersey 08854

3. ImQuest Biosciences, Inc., 7340 Executive Way, Suite R, Frederick, Maryland 21704

4. Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901167t

Reference38 articles.

1. DNA Polymerases versus HIV Reverse Transcriptase in AIDS Therapy

2. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

3. The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1.