Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin-Reference-Cited by-同舟云学术

Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin

Published:2004-01-31 Issue:5 Volume:47 Page:1290-1298
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jeyadevan J. Prince¹,Bray Patrick G.¹,Chadwick James¹,Mercer Amy E.¹,Byrne Aoife¹,Ward Stephen A.¹,Park B. Kevin¹,Williams Dominic P.¹,Cosstick Rick¹,Davies Jill¹,Higson Adrian P.¹,Irving Ed¹,Posner Gary H.¹,O'Neill Paul M.¹

Affiliation:

1. Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, U.K., Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3GE, U.K., Liverpool School of Tropical Medicine, University of Liverpool, Liverpool L69 3GE, U.K., UFC Ltd., Synergy House, Guildhall Close, Manchester Science Park, Manchester M15 6SY, U.K., and Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, Maryland 21218

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030974c

Reference45 articles.

1. EPR Evidence for the Involvement of Free Radicals in the Iron-Catalysed Decomposition of Qinghaosu (Artemisinin) and Some Derivatives; Antimalarial Action of Some Polycyclic Endoperoxides

2. The biomimetic iron-mediated degradation of arteflene (Ro-42-1611),an endoperoxide antimalarial: Implications for the mechanism of antimalarial activity

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