Hydroxypropyl Methylcellulose Mediated Precipitation Inhibition of Sirolimus: From a Screening Campaign to a Proof-of-Concept Human Study-Reference-Cited by-同舟云学术

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Hydroxypropyl Methylcellulose Mediated Precipitation Inhibition of Sirolimus: From a Screening Campaign to a Proof-of-Concept Human Study

Published:2013-05-06 Issue:6 Volume:10 Page:2299-2310
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Petruševska Marija¹,Homar Miha¹,Petek Boštjan¹,Resman Aleksander¹,Kocjan Darko²,Urleb Uroš³,Peternel Luka¹

Affiliation:

1. Sandoz Development Center Slovenia, Pharmaceutical and Biological Profiling, Lek Pharmaceuticals d.d., 1526 Ljubljana, Slovenia

2. EN-FIST Centre of Excellence, 1000 Ljubljana, Slovenia

3. Sandoz International, Global Product Development, 83607 Holzkirchen, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp300641h

Reference55 articles.

1. Supersaturating Drug Delivery Systems: The Answer to Solubility-Limited Oral Bioavailability?

2. Characterization of Supersaturatable Formulations for Improved Absorption of Poorly Soluble Drugs

3. Combined Use of Crystalline Salt Forms and Precipitation Inhibitors to Improve Oral Absorption of Celecoxib from Solid Oral Formulations

4. Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: Basic approaches and practical applications

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3. Concentration and composition dependent aggregation of Pluronic- and Poly-(2-oxazolin)-Efavirenz formulations in biorelevant media;Journal of Colloid and Interface Science;2022-01

4. Rapid screening approaches for solubility enhancement, precipitation inhibition and dissociation of a cocrystal drug substance using high throughput experimentation;Journal of Drug Delivery Science and Technology;2021-02

5. Approaches to increase mechanistic understanding and aid in the selection of precipitation inhibitors for supersaturating formulations – a PEARRL review;Journal of Pharmacy and Pharmacology;2018-05-16

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