Inhibitors of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1): Identification of (S)-7-(2-Fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5′H-spiro[chromeno[2,3-b]pyridine-5,4′-oxazol]-2′-amine (AMG-8718)-Reference-Cited by-同舟云学术

Inhibitors of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1): Identification of (S)-7-(2-Fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5′H-spiro[chromeno[2,3-b]pyridine-5,4′-oxazol]-2′-amine (AMG-8718)

Published:2014-11-14 Issue:23 Volume:57 Page:9811-9831
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dineen Thomas A.¹,Chen Kui¹,Cheng Alan C.¹,Derakhchan Katayoun¹,Epstein Oleg¹,Esmay Joel¹,Hickman Dean¹,Kreiman Chuck E.¹,Marx Isaac E.¹,Wahl Robert C.¹,Wen Paul H.¹,Weiss Matthew M.¹,Whittington Douglas A.¹,Wood Stephen¹,Fremeau Robert T.¹,White Ryan D.¹,Patel Vinod F.¹

Affiliation:

1. Departments of Therapeutic Discovery, ‡Neuroscience, §Molecular Structure and Characterization, ∥Pharmacokinetics and Drug Metabolism, and ⊥Comparative Biology and Safety Sciences, Amgen, Inc., 360 Binney Street, Cambridge, Massachusetts 02142, and One Amgen Center Drive, Thousand Oaks, California 91320, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5012676

Reference56 articles.

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