Optimization of the Reduction of a 5-Benzylidenethiazolidine-2,4-dione Derivative Supported by the Reaction Response Surface Analysis: Synthesis of Pioglitazone Hydrochloride
Author:
Affiliation:
1. Pharmaceutical Research Institute, Rydygiera 8, 01-793 Warsaw, Poland, and Department of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op0300286
Reference24 articles.
1. Synthesis and Biological Activity of Metabolites of the Antidiabetic, Antihyperglycemic Agent Pioglitazone
2. Studies on Antidiabetic Agents. XII. Synthesis and Activity of the Metabolites of (.+-.)-5-(p-(2-(5-Ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione (Pioglitazone).
3. Pioglitazone
4. Studies on hindered phenols and analogs. 1. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation
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