Biarylpyrazole Inverse Agonists at the Cannabinoid CB1 Receptor: Importance of the C-3 Carboxamide Oxygen/Lysine3.28(192) Interaction-Reference-Cited by-同舟云学术

Biarylpyrazole Inverse Agonists at the Cannabinoid CB1 Receptor: Importance of the C-3 Carboxamide Oxygen/Lysine3.28(192) Interaction

Published:2006-09-01 Issue:20 Volume:49 Page:5969-5987
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hurst Dow¹,Umejiego Uju¹,Lynch Diane¹,Seltzman Herbert¹,Hyatt Steven¹,Roche Michael¹,McAllister Sean¹,Fleischer Daniel¹,Kapur Ankur¹,Abood Mary¹,Shi Shanping¹,Jones Jannie¹,Lewis Deborah¹,Reggio Patricia¹

Affiliation:

1. Center for Drug Design, Chemistry and Biochemistry Department, University of North Carolina Greensboro, P.O. Box 26170, 435 New Science Building, Greensboro, North Carolina 27402-6170, Chemistry & Life Sciences, RTI International, 3040 Cornwallis Road, Research Triangle Park, North Carolina 27709, California Pacific Medical Center Research Institute, 475 Brannan Street, Suite 220, San Francisco, California 94107, and Pharmacology and Toxicology Department, Medical College of Georgia, Augusta, Georgia 30912

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060446b

Reference54 articles.

1. N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A) Interaction with LYS 3.28(192) Is Crucial for Its Inverse Agonism at the Cannabinoid CB1 Receptor

2. Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor

3. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

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