Treatment of Breast and Lung Cancer Cells with a N-7 Benzyl Guanosine Monophosphate Tryptamine Phosphoramidate Pronucleotide (4Ei-1) Results in Chemosensitization to Gemcitabine and Induced eIF4E Proteasomal Degradation-Reference-Cited by-同舟云学术

Treatment of Breast and Lung Cancer Cells with a N-7 Benzyl Guanosine Monophosphate Tryptamine Phosphoramidate Pronucleotide (4Ei-1) Results in Chemosensitization to Gemcitabine and Induced eIF4E Proteasomal Degradation

Published:2013-01-04 Issue:2 Volume:10 Page:523-531
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Li Shui¹,Jia Yan¹,Jacobson Blake¹,McCauley Joel¹,Kratzke Robert¹,Bitterman Peter B.¹,Wagner Carston R.¹

Affiliation:

1. Department of Medicinal Chemistry and ‡Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp300699d

Reference52 articles.

1. Activation of Akt and eIF4E Survival Pathways by Rapamycin-Mediated Mammalian Target of Rapamycin Inhibition

2. Tumor-specific RNAi targeting eIF4E suppresses tumor growth, induces apoptosis and enhances cisplatin cytotoxicity in human breast carcinoma cells

3. Detection of the proto-oncogene eIF4E in surgical margins may predict recurrence in head and neck cancer

4. Eukaryotic initiation factor-4E in superficial and muscle invasive bladder cancer and its correlation with vascular endothelial growth factor expression and tumour progression

5. eIF-4E expression is associated with histopathologic grades in cervical neoplasia

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