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Rationalizing Lead Optimization by Associating Quantitative Relevance with Molecular Structure Modification

  • Published:2009-07-15 Issue:8 Volume:49 Page:1952-1962
  • ISSN:1549-9596
  • Container-title:Journal of Chemical Information and Modeling
  • language:en
  • Short-container-title:J. Chem. Inf. Model.

Author:

Raymond John W.1,Watson Ian A.1,Mahoui Abdelaziz1

Affiliation:

1. Discovery Informatics and Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Reference37 articles.

1. Utilization of operational schemes for analog synthesis in drug design

2. Sneader, W.Drug Prototypes and Their Exploitation;John Wiley & Sons:Chichester, 1996; p788.

3. Bioisosterism:  A Rational Approach in Drug Design

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