A Simplified Process for the Manufacture of Imagabalin Hydrochloride (PD-0332334), an α2δ-Ligand for the Treatment of Generalised Anxiety Disorder-Reference-Cited by-同舟云学术

A Simplified Process for the Manufacture of Imagabalin Hydrochloride (PD-0332334), an α2δ-Ligand for the Treatment of Generalised Anxiety Disorder

Published:2011-10-11 Issue:6 Volume:15 Page:1358-1364
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Birch Melissa¹,Challenger Stephen¹,Crochard Jean-Philippe¹,Fradet David¹,Jackman Hayley¹,Luan Amy¹,Madigan Evelyn¹,Mathew Jinu S.¹,McDowall Neil¹,Meldrum Kevin¹,Gordon Charles M.¹,Peach Philip¹,Yeo Stephen¹

Affiliation:

1. Department of Chemical Research and Development, Pfizer World Wide Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op2002326

Reference29 articles.

1. Diastereoselective, large-scale synthesis of β-amino acids via asymmetric aza-Michael addition as α2δ ligands for the treatment of generalized anxiety disorder and insomnia

2. The Development of a Practical Multikilogram Synthesis of the Chiral β-Amino Acid Imagabalin Hydrochloride (PD-0332334) via Asymmetric Hydrogenation

3. A Facile Deprotection of Secondary Acetamides

4. Matsumura, K.; Zhang, X.; Saito, T.EP/2004/1386901 A1 2004;

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