TgCRND8 Amyloid Precursor Protein Transgenic Mice Exhibit an Altered γ-Secretase Processing and an Aggressive, Additive Amyloid Pathology Subject to Immunotherapeutic Modulation

Author:

Van Vickle Gregory D.1,Esh Chera L.1,Kalback Walter M.1,Patton R. Lyle1,Luehrs Dean C.1,Kokjohn Tyler A.1,Fifield Frederick G.1,Fraser Paul E.1,Westaway David1,McLaurin Joanne1,Lopez John1,Brune Daniel1,Newel Amanda J.1,Poston Marissa1,Beach Thomas G.1,Roher Alex E.1

Affiliation:

1. The Longtine Center for Molecular Biology and Genetics and W. H. Civin Laboratory of Neuropathology, Sun Health Research Institute, Sun City, Arizona 85351, Department of Microbiology, Midwestern University, Glendale, Arizona 85308, Pathology Section, Sun Health Boswell Hospital, Sun City, Arizona 85851, Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario M5S 3H2, Canada, and Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

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