Biochemical and Biophysical Analysis of a Chiral PqsD Inhibitor Revealing Tight-binding Behavior and Enantiomers with Contrary Thermodynamic Signatures-Reference-Cited by-同舟云学术

Biochemical and Biophysical Analysis of a Chiral PqsD Inhibitor Revealing Tight-binding Behavior and Enantiomers with Contrary Thermodynamic Signatures

Published:2013-10-25 Issue:12 Volume:8 Page:2794-2801
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Storz Michael P.¹,Brengel Christian¹,Weidel Elisabeth¹²,Hoffmann Michael³,Hollemeyer Klaus⁴,Steinbach Anke¹,Müller Rolf³,Empting Martin¹,Hartmann Rolf W.¹²

Affiliation:

1. Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Department Drug Design and Optimization, Campus C2.3, 66123 Saarbrücken, Germany

2. Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2.3, 66123 Saarbrücken, Germany

3. Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Department Microbial Natural Products, Campus C2.3, 66123 Saarbrücken, Germany

4. Biochemical Engineering, Saarland University, Campus A1.5, 66123 Saarbrücken, Germany

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/cb400530d

Reference31 articles.

1. Antibacterial resistance worldwide: causes, challenges and responses

2. Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia.

3. Outer membrane barrier as a mechanism of antimicrobial resistance

4. Biochemical mechanisms of drug action: what does it take for success?

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