Synthesis, Biological Evaluation, And Molecular Modeling of Chalcone Derivatives As Potent Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatases (PtpA and PtpB)

Author:

Chiaradia Louise Domeneghini12,Martins Priscila Graziela Alves1,Cordeiro Marlon Norberto Sechini2,Guido Rafael Victorio Carvalho3,Ecco Gabriela1,Andricopulo Adriano Defini3,Yunes Rosendo Augusto2,Vernal Javier1,Nunes Ricardo José2,Terenzi Hernán1

Affiliation:

1. Centro de Biologia Molecular Estrutural, CEBIME−UFSC, Universidade Federal de Santa Catarina, Campus Trindade, 88040−900 Florianópolis−SC, Brasil

2. Laboratório Estrutura e Atividade, Departamento de Química, LEAT−CFM−UFSC, Universidade Federal de Santa Catarina, Campus Trindade, 88040−900 Florianópolis−SC, Brasil

3. Laboratório de Química Medicinal e Computacional, Instituto de Física de São Carlos, Universidade de São Paulo, Av. Trabalhador São-Carlense 400, 13560−970 São Carlos−SP, Brasil.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference90 articles.

1. aTuberculosis; available inhttp://www.who.int/topics/tuberculosis/en/(accessed January 11, 2011).

2. bGlobal Tuberculosis Control: Epidemiology, Strategy, Financing: WHO Report 2009;World Health Organization:Geneva, 2009; 314 pp. Available inhttp://www.who.int/tb/publications/global_report/2009/pdf/full_report.pdf(accessed January 14, 2011).

3. cTB/HIV Co-infection; available inhttp://apps.who.int/tdr/svc/diseases/tb–hiv(accessed January 11 2011).

4. Diagnóstico y tratamiento de la tuberculosis

5. New Small-Molecule Synthetic Antimycobacterials

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