Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity: Design, Synthesis, and X-ray Cocrystal Structure-Reference-Cited by-同舟云学术

Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity: Design, Synthesis, and X-ray Cocrystal Structure

Published:2002-10-15 Issue:23 Volume:45 Page:4961-4974
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Canan Koch Stacie S.¹,Thoresen Lars H.¹,Tikhe Jayashree G.¹,Maegley Karen A.¹,Almassy Robert J.¹,Li Jianke¹,Yu Xiao-Hong¹,Zook Scott E.¹,Kumpf Robert A.¹,Zhang Cathy¹,Boritzki Theodore J.¹,Mansour Rena N.¹,Zhang Kanyin E.¹,Ekker Anne¹,Calabrese Chris R.¹,Curtin Nicola J.¹,Kyle Suzanne¹,Thomas Huw D.¹,Wang Lan-Zhen¹,Calvert A. Hilary¹,Golding Bernard T.¹,Griffin Roger J.¹,Newell David R.¹,Webber Stephen E.¹,Hostomsky Zdenek¹

Affiliation:

1. Pfizer Global Research and Development, La Jolla/Agouron Pharmaceuticals, Inc., 10770 Science Center Drive, San Diego, California 92121, and University of Newcastle, Newcastle upon Tyne, NE2 4HH, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm020259n

Reference52 articles.

1. A Human Poly(ADP-ribose) Polymerase Gene Family (ADPRTL): cDNA Cloning of Two Novel Poly(ADP-ribose) Polymerase Homologues

2. The nuclear protein PH5P of the inter-α-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-α-inhibitor family and a novel actor of DNA repair?

3. The 193-Kd Vault Protein, Vparp, Is a Novel Poly(Adp-Ribose) Polymerase

4. Tankyrase, a Poly(ADP-Ribose) Polymerase at Human Telomeres

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