Synthesis and Biological Evaluation of Novel Allosteric Enhancers of the A1 Adenosine Receptor Based on 2-Amino-3-(4′-Chlorobenzoyl)-4-Substituted-5-Arylethynyl Thiophene-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of Novel Allosteric Enhancers of the A1 Adenosine Receptor Based on 2-Amino-3-(4′-Chlorobenzoyl)-4-Substituted-5-Arylethynyl Thiophene

Published:2014-09-12 Issue:18 Volume:57 Page:7673-7686
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Romagnoli Romeo¹,Baraldi Pier Giovanni¹,IJzerman Adriaan P.²,Massink Arnault²,Cruz-Lopez Olga¹,Lopez-Cara Luisa Carlota¹,Saponaro Giulia¹,Preti Delia¹,Aghazadeh Tabrizi Mojgan¹,Baraldi Stefania¹,Moorman Allan R.³,Vincenzi Fabrizio⁴,Borea Pier Andrea⁴,Varani Katia⁴

Affiliation:

1. Dipartimento di Scienze Chimiche e Farmaceutiche, Università di Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara, Italy

2. Leiden Academic Centre for Drug Research, Division of Medicinal Chemistry, P.O. Box 9502, 2300 RA Leiden, The Netherlands

3. King Pharmaceuticals Inc., Research and Development, 4000 CentreGreen Way, Suite 300, Cary, North Carolina 27513

4. Dipartimento di Scienze Mediche, Sezione di Farmacologia, Università di Ferrara, Via Savonarola 9, 44121 Ferrara, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5008853

Reference52 articles.

1. Adenosine, an endogenous distress signal, modulates tissue damage and repair

2. Purine and pyrimidine receptors

3. Adenosine receptors as therapeutic targets

4. Adenosine receptor targeting in health and disease

5. ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

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