Discovery and Optimization of a Novel Series of N-Arylamide Oxadiazoles as Potent, Highly Selective and Orally Bioavailable Cannabinoid Receptor 2 (CB2) Agonists-Reference-Cited by-同舟云学术

Discovery and Optimization of a Novel Series of N-Arylamide Oxadiazoles as Potent, Highly Selective and Orally Bioavailable Cannabinoid Receptor 2 (CB2) Agonists

Published:2008-08-01 Issue:16 Volume:51 Page:5019-5034
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cheng Yuan¹,Albrecht Brian K.¹,Brown James¹,Buchanan John L.¹,Buckner William H.¹,DiMauro Erin F.¹,Emkey Renee¹,Fremeau Robert T.¹,Harmange Jean-Christophe¹,Hoffman Beth J.¹,Huang Liyue¹,Huang Ming¹,Lee Josie Han¹,Lin Fen-Fen¹,Martin Matthew W.¹,Nguyen Hung Q.¹,Patel Vinod F.¹,Tomlinson Susan A.¹,White Ryan D.¹,Xia Xiaoyang¹,Hitchcock Stephen A.¹

Affiliation:

1. Chemistry Research and Discovery, Department of Molecular Structure, Department of Neuroscience, Department of Protein Science, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, Chemistry Research and Discovery, Department of HTS and Molecular Pharmocology, Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., 1 Kendall Square Building 1000, Cambridge, Massachusetts 02139

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800463f

Reference34 articles.

1. Molecular characterization of a peripheral receptor for cannabinoids

2. Structure of a cannabinoid receptor and functional expression of the cloned cDNA

3. Cannabinoid receptor localization in brain.

4. Altered gene expression in striatal projection neurons in CB1 cannabinoid receptor knockout mice

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