Mechanistic Studies of a Skatole-Forming Glycyl Radical Enzyme Suggest Reaction Initiation via Hydrogen Atom Transfer-Reference-Cited by-同舟云学术

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Mechanistic Studies of a Skatole-Forming Glycyl Radical Enzyme Suggest Reaction Initiation via Hydrogen Atom Transfer

Published:2022-06-15 Issue:25 Volume:144 Page:11110-11119
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Fu Beverly¹^ORCID,Nazemi Azadeh²^ORCID,Levin Benjamin J.¹^ORCID,Yang Zhongyue²^ORCID,Kulik Heather J.²^ORCID,Balskus Emily P.¹³^ORCID

Affiliation:

1. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States

2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

3. Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, United States

Funder

Howard Hughes Medical Institute

Bill and Melinda Gates Foundation

U.S. Department of Energy

Burroughs Wellcome Fund

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.1c13580

Reference41 articles.

1. Revised Estimates for the Number of Human and Bacteria Cells in the Body

2. p-Hydroxyphenylacetate decarboxylase from Clostridium difficile

3. Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole

4. The metabolic basis of 3-methylindole-induced pneumotoxicity

5. Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes

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1. Modeling the Initiation Phase of the Catalytic Cycle in the Glycyl-Radical Enzyme Benzylsuccinate Synthase;The Journal of Physical Chemistry B;2024-06-07

2. Magnolol-driven microbiota modulation elicits changes in tryptophan metabolism resulting in reduced skatole formation in pigs;Journal of Hazardous Materials;2024-01

3. Unraveling the Conversion of Fatty Acids into Terminal Alkenes by an Integral Membrane Enzyme, UndB;ACS Catalysis;2023-11-17

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