Discovery of Novel, Potent, and Selective Inhibitors of 3-Phosphoinositide-Dependent Kinase (PDK1)-Reference-Cited by-同舟云学术

Discovery of Novel, Potent, and Selective Inhibitors of 3-Phosphoinositide-Dependent Kinase (PDK1)

Published:2011-11-23 Issue:24 Volume:54 Page:8490-8500
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Murphy Sean T.¹,Alton Gordon¹,Bailey Simon¹,Baxi Sangita M.¹,Burke Benjamin J.¹,Chappie Thomas A.²,Ermolieff Jacques¹,Ferre RoseAnn¹,Greasley Samantha¹,Hickey Michael¹,Humphrey John²,Kablaoui Natasha³,Kath John¹,Kazmirski Steven³,Kraus Michelle¹,Kupchinsky Stan¹,Li John¹,Lingardo Laura¹,Marx Matthew A.¹,Richter Dan¹,Tanis Steven P.¹,Tran Khanh¹,Vernier William¹,Xie Zhi¹,Yin Min-Jean¹,Yu Xiao-Hong¹

Affiliation:

1. Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121, United States

2. Pfizer Global Research and Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States

3. Pfizer Global Research and Development, 620 Memorial Drive, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201019k

Reference31 articles.

1. Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

2. PDK1, the master regulator of AGC kinase signal transduction

3. Targeting PDK1 in Cancer

4. Hypomorphic Mutation of PDK1 Suppresses Tumorigenesis in PTEN+/− Mice

Cited by 28 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Pharmacological activity and mechanism of pyrazines;European Journal of Medicinal Chemistry;2023-10

2. Emerging roles of noncoding RNAs in human cancers;Discover Oncology;2023-07-13

3. Solubility Measurement and Correlation of 2-Amino-5-bromopyrazine in Methanol/Ethanol/Isopropanol/Propylene Glycol Plus Water and 10 Pure Solvents at (278.15-323.15) K;J CHEM ENG DATA;2023

4. Solubility Measurement and Correlation of 2-Amino-5-bromopyrazine in Methanol/Ethanol/Isopropanol/Propylene Glycol Plus Water and 10 Pure Solvents at (278.15–323.15) K;Journal of Chemical & Engineering Data;2023-01-27

5. Solubility Measurement and Correlation of 2-Amino-3-chloropyrazine and 2-Amino-3,5-dibromopyrazine in a Series of Mixed Solvent Systems at T = (278.15 to 323.15) K;Journal of Chemical & Engineering Data;2022-06-27